Pre-clinical and Clinical Investigation of the Impact of Obesity on Ovarian Cancer Pathogenesis

s presented: (1) Zhou, C, Zhong, Y, Du, X, Makowski, L, Jia, W and Bae-Jump, VL, Diet-induced obesity increases tumor aggressiveness in a genetically engineered mouse model of serous ovarian cancer, Oral Presentation by Dr. Bae-Jump at the 2013 Annual Meeting of the Society of Gynecologic Oncology. Manuscripts submitted: Figure 8. Metformin inhibited tumor growth in non-obese and obese KpB mice. In obese mice, metformin decreased tumor growth by 60% compared to obese control animals. Tumor growth was only decreased by 32% in the non-obese mice compared to non-obese controls. A comparison of the antitumorigenic effects of metformin on ovarian tumors from nonobese and obese mice demonstrated that metformin was more efficacious in obese mice (p=0.003), suggesting that metformin may be more beneficial in the setting of obesity.